浙江大学蔡杰研究员简介
时间:2025-10-03 次数:11
来源:中国畜牧兽医学会动物福利与健康养殖分会

      蔡杰,博士,浙江大学研究员,博士生导师。主持国自然青年基金和重点项目子课题等5项。现为中国畜牧兽医学会高级会员,中国畜牧兽医学会动物福利与健康养殖分会常务理事。以第一/通讯作者身份在Nature Communications、Advanced Science(封面)、Environment International、FASEB Journal, Genomics等国际著名学术期刊及Animal Nutrition, Journal of Animal Science and Biotechnology等行业顶级学术刊物上发表SCI论文20余篇,申请及授权专利7项。入选“浙江大学百人计划”、珠峰英才计划创新团队。获中国商业联合会科学技术奖特等奖1项。目前担任Cell子刊(One Earth)等国际著名杂志的特邀审稿人,以及Animal Nutriomics杂志的青年编委。担任浙江省及杭州市博士创新站首席专家。完成团体标准1项。

目前,研究方向主要是动物代谢失衡及其调控技术,富有特色地建立了系列研发平台,包括:1)人工智能驱动的泛化式药物分子开发;2)细胞表型组无损检测平台及技术;3)生物合成及天然产物生产集成平台,结合人工智能-合成生物学-分子化学学科交叉技术,研发对肝脏、乳腺、卵巢等关键器官的靶向活性分子,形成稳态调控的精准方案。

代表性成果:

1. Cai J*, Peng J, Feng Juan, Li RC, Ren P, Zang XW, Wu ZZ, Lu Y, Luo L, Hu ZZ, Wang JY, Dai XM, Zhao P, Wang J, Yan M, Liu JX, Deng RR*, Wang DM*. Antioxidant hepatic lipid metabolism can be promoted by orally administered inorganic nanoparticles. Nature Communications. 2023;14:3643. doi: 10.1038/s41467-023-39423-3. (IF5 = 17.8)

2. Cai J, Peng J, Zang XW, Feng Juan, Li RC, Ren P, Zheng BZ, Wang JY, Wang J, Liu JX, Deng RR*, Wang DM*. Mammary leukocyte-assisted nanoparticle transport enhances targeted milk trace mineral delivery. Advanced Science. 2022;9(26):e2200841. doi: 10.1002/advs.202200841.(IF5 = 18.9)(封面文章)

3. Cai J, Miao C, Chen Y, Xie Y, Liu J, Wang D. Nano-sized zinc addition enhanced mammary zinc translocation without altering health status of dairy cows. Animal Nutrition. 2021;7(4):1024-1030. doi:10.1016/j.aninu.2021.06.003 (IF = 6.4).

4. Cai J, Wang D, Zhao FQ, Liang S, Liu J. AMPK-mTOR pathway is involved in glucose-modulated amino acid sensing and utilization in the mammary glands of lactating goats. Journal of Animal Science and Biotechnology. 2020;11:32. doi:10.1186/s40104-020-0434-6 (IF5 = 5.9).

5. Cai J, Wang D, Liang S, Peng J, Zhao F, Liu J. Excessive supply of glucose elicits an NF-κB2-dependent glycolysis in lactating goat mammary glands. FASEB Journal. 2020;34(6):8671-8685. doi:10.1096/fj.201903088R (IF5 = 6.0).

6. Cai J, Zang X, Wu Z, Liu J, Wang D. Translocation of transition metal oxide nanoparticles to breast milk and offspring: The necessity of bridging mother-offspring-integration toxicological assessments. Environment International. 2019;133(Pt A):105153. doi:10.1016/j.envint.2019.105153(IF5 = 13.2).